Progressi della ricerca sulle
cellule staminali per la Sclerosi Laterale
Advances in stem cell research for
2009 Oct 9. [Epub ahead of print]
Johns Hopkins University, 600 N. Wolfe St., Meyer 6-119, Baltimore, MD 21287, United States.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized primarily by motor neuron loss in the motor cortex and spinal cord leading to progressive disability and death. Despite the relative selectivity of motor neuron loss, recent studies have implicated other cell types including astrocytes and microglia as contributors to this cell death. This understanding has resulted in stem-cell-replacement strategies of these cell types, which may result in neuroprotection. In addition to cell-replacement strategies, the development of induced pluripotent stem cell (iPSC) technologies has resulted in the establishment of motor neuron cell lines from patients with ALS. The use of iPSCs from ALS patients will allow for potential autologous cell transplantation, drug discovery, and an increased understanding of ALS pathobiology.
PMID: 19819686 [PubMed - as supplied by publisher]
Johns Hopkins University, 600 N. Wolfe St., Meyer 6-119, Baltimore, MD 21287, United States.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized primarily by motor neuron loss in the motor cortex and spinal cord leading to progressive disability and death. Despite the relative selectivity of motor neuron loss, recent studies have implicated other cell types including astrocytes and microglia as contributors to this cell death. This understanding has resulted in stem-cell-replacement strategies of these cell types, which may result in neuroprotection. In addition to cell-replacement strategies, the development of induced pluripotent stem cell (iPSC) technologies has resulted in the establishment of motor neuron cell lines from patients with ALS. The use of iPSCs from ALS patients will allow for potential autologous cell transplantation, drug discovery, and an increased understanding of ALS pathobiology.
PMID: 19819686 [PubMed - as supplied by publisher]
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Progressi della ricerca sulle cellule staminali per la Sclerosi Laterale
Sclerosi Laterale Amiotrofica (SLA) è una malattia neurodegenerativa caratterizzata principalmente dalla perdita dei motoneuroni nella corteccia motoria e nel midollo spinale conduce alla disabilità progressiva e morte. Nonostante la selettività relativa perdita dei motoneuroni, recenti studi hanno coinvolto altri tipi di cellule tra cui astrociti e microglia come contributori a questa morte cellulare. Questa comprensione ha portato a cellule staminali-strategie di sostituzione di questi tipi di cellule, che possono comportare neuroprotezione. In aggiunta alle strategie di sostituzione cellulare, lo sviluppo di cellule staminali pluripotenti indotte (IPSC) tecnologie ha portato alla creazione di linee di neurone motore di cellule da pazienti affetti da SLA. L'uso di iPSCs da pazienti affetti da SLA consentirà per il potenziale di trapianto di cellule autologhe, scoperta di nuovi farmaci, e un patobiologia maggiore comprensione della SLA.
PMID: 19819686 [PubMed - come fornito a cura dell'editore]
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